Antibiotic therapy in autoimmune disorders
نویسندگان
چکیده
Department of Medicine D, Sheba Medical Center, Tel Hashomer, Israel Division of Rheumatology, Sheba Medical Center, Tel Hashomer, Israel Autoimmune Disease Center, Sheba Medical Center, Tel Hashomer, Israel Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel *Author for correspondence: [email protected] SUMMARY: Antibiotics have been applied for the treatment of autoimmune diseases for over five decades, based on the premise that infections play a role in the initiation and propagation of these entities. The mechanisms by which an infection may trigger an autoimmune reaction include the so-called ‘molecular mimicry’, ‘epitope spreading’ or ‘bystander activation’. The association between infection and autoimmunity may be directly evident, as in cases of reactive arthritis, or in a more roundabout manner, as exemplified by the association between anaerobic bacterial infection of the gums and rheumatoid arthritis. Moreover, some antibiotics have, in addition to Practice Points
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